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                                                                          學術活動
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                                                                          网赌正规网站网址:On improving CRISPR gene editing technology
                                                                          發表時間:2019-03-26 閱讀次數:118次

                                                                          主講人:趙雲德

                                                                          美國加州大學SanDiego分校植物科學系系主任教授、“千人計劃”特聘專家、“長江學者”講座教授

                                                                          時 間:2019年4月4日10:00-11:30

                                                                          地 點:上海交通大學閔行校區生物藥學樓樹華報告廳

                                                                          趙雲德,博士 ,美國加州大學分校終身教授、中組部“千人計劃”特聘專家、南京農業大學“長江學者”講座教授。1990年於中國科學院上海藥物研究所獲微生物學碩士學位後赴美留學 ,在美國密歇根大學獲博士學位 ,畢業後在著名的The Salk Institute進行博士後工作 。主要從事生長素在發育過程中的作用機理方面的研究,在植物生長素的合成、修飾、運輸和信號轉導的分子機理研究領域取得多項突破性成果 。以第一作者或通訊作者身份在Science、Cell、Gene and Development、PNAS、Plant Cell等國際著名期刊上發表多篇學術論文篇,包括應邀爲Annual Review of Plant Biology等雜誌所撰寫的綜述 。文章引用數超過10000次, H指數51。

                                                                          報告簡介

                                                                          CRISPR gene editing technologies have revolutionized biology and crop improvement. In this presentation, I will first describe the remaining challenges of gene editing technologies in plants followed by presenting our effort in improving several aspects of CRISPR gene editing technology. I will focus on two main areas of CRISPR technology: Homology-directed DNA repair (HDR) and transgene-free genome editing. HDR has been regarded as the Holy Grail of genome editing in plants and offers unprecedented applications in agriculture. We have developed new strategies that enabled HDR-based gene replacements in plants. Transgene-free is likely a prerequisite to gain regulatory approval of edited crops. My group has pioneered several strategies that accelerate the isolation of transgene-free, gene-edited plants. Our latest technology allows the isolation of edited, transgene-free plants within a single generation, greatly accelerating crop breeding. I will use editing auxin pathways as an example to demonstrate the power of our new technologies in both basic and applied plant biology.

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